Preheat the oven to 250°F. Line a large rimmed baking sheet with parchment paper or foil.
Whisk the apple cider vinegar and hot sauce together in a small bowl. Set aside.
Remove the thin membrane from the bone side of the ribs.
Place the ribs on the prepared baking sheet, bone side down. If the ribs are too large, use two baking sheets.
Spray the tops of the ribs with the cooking spray and sprinkle with garlic powder, onion powder, smoked paprika, smoked salt, and black pepper.
Bake the ribs uncovered for 1 hour. Remove from the oven.
Stir the apple cider and hot sauce mixture, then baste the tops of the ribs with ⅓ of the marinade.
Return the ribs to the oven and continue to bake, uncovered, for 3 hours. Baste the ribs with the remaining marinade every hour. Be sure to wash the basting brush thoroughly after using it each time.
The ribs should be brown and very tender after 4 hours of baking. Reduce the oven to 200°F and bake for 1 more hour for ribs that are fall-apart tender and beautifully caramelized.
Remove the ribs from the oven, slice them into individual servings and enjoy with your favorite sides.